Viewing data from:

DEPO-ESTRADIOL

ANDA

ESTRADIOL CYPIONATE | A085470 | PFIZER INC

3 strengths0 unique patents0 unique exclusivities

Drug Pricing (NADAC)

National Average Drug Acquisition Cost — Week of 2026-07-15 | 1 NDC

Highest NADAC/Unit

$51.91

per ml

Lowest NADAC/Unit

$51.91

per ml

Brand NDCs

Generic NDCs

NDC Description	NADAC/Unit	Unit	Type	Generic NADAC	Effective
00009027101DEPO-ESTRADIOL 5 MG/ML VIAL	$51.91	ML	—	—	2026-07-01

Source: NADAC (data.medicaid.gov). Prices reflect national average acquisition costs for retail community pharmacies.

VA Federal Supply Schedule

Government-negotiated contract prices | 1 NDC (1 FSS)

Lowest Price

$165.60

Highest Price

$165.60

FSS NDCs

Big4 NDCs

Description	Price	Type	Vendor	Contract End
00009-0271-01DEPO-ESTRADIOL CYPIONATE 5MG/ML INJ	$165.60	FSS	Pfizer Inc.	06/30/2029

Source: VA Federal Supply Schedule (va.gov). Prices are government-negotiated contract prices.

Medicare Part D Spending

CMS annual spending data for Depo-Estradiol (2024)

Total Spending

$670K

Total Claims

3,076

Beneficiaries

1,595

Avg Cost/Unit

$37.40

Spending Trend

$1.1M(2019)→$1.2M(2020)→$1.2M(2021)→$780K(2022)→$681K(2023)→$670K(2024)

YoY Change:+9.6%

5yr CAGR:+12.1%

Source: CMS Medicare Part D Spending by Drug (2024). Shows gross drug cost under Part D.

Medicare Part B Spending

CMS physician-administered drug spending for Depo-Estradiol (2024)

Total Spending

$114K

Total Claims

3,721

Beneficiaries

807

ASP Price

$37.37

Spending Trend

$274K(2019)→$235K(2020)→$212K(2021)→$136K(2022)→$104K(2023)→$114K(2024)

YoY Change:+16.6%

5yr CAGR:+10.6%

HCPCS: J1000 — Injection, depo-estradiol cypionate, up to 5 mg

Source: CMS Medicare Part B Spending by Drug (2024). Shows physician-administered drug costs.

API Supply Chain1 active DMF2 inactive

1 active API supplier hold Drug Master Files for this ingredient. Limited supplier base — potential supply chain risk.

PHARMACIA AND UPJOHN CO WHOLLY OWNED SUB PFIZER INCESTRADIOL CYPIONATE USP

DMF 50471983

DIOSYNTH BVInactiveESTRADIOL CYPIONATE

DMF 29921977

DIOSYNTH INCInactiveESTRADIOL CYPIONATE

DMF 38331980

Source: FDA Drug Master Files (fda.gov). Type II API DMFs matched by ingredient.

Products (3)

Sort:

#001 — 1MG/ML

0 patents0 exclusivities▴

INJECTABLE;INJECTION | Approved: Approved Prior to Jan 1, 1982

No patent or exclusivity listings for this strength.

#002 — 3MG/ML

0 patents0 exclusivities▾

INJECTABLE;INJECTION | Approved: Approved Prior to Jan 1, 1982

#003 — 5MG/ML

0 patents0 exclusivities▾

INJECTABLE;INJECTION | Approved: Approved Prior to Jan 1, 1982